Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …

Mitochondrial dysfunction and synaptic damage are early pathological features of the
Alzheimer's disease-affected brain. Memory impairment in Alzheimer's disease is a …

Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

Various environmental and genetic factors influence the onset and progression of
Alzheimer's disease (AD). Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis …

The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

Abstract Toll-like receptor 4 (TLR4) signaling in the brain mediates autoimmune responses
and induces neuroinflammation that results in neurodegenerative diseases, such as …