The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Several of the most important discoveries in the field of membrane traffic have come from
studies of Rab GTPases by Marino Zerial and Peter Novick and their colleagues. Zerial was …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

Sequential transport from early to late endosomes requires the coordinated activities of the
small GTPases Rab5 and Rab7. The transition between early and late endosomes could be …

Although the exact etiology of Alzheimer's disease (AD) is a topic of debate, the consensus
is that the accumulation of β-amyloid (Aβ) peptides in the senile plaques is one of the …

Endocytosis of cell surface receptors is an important regulatory event in signal transduction.
The transforming growth factor β (TGF-β) superfamily signals to the Smad pathway through …