Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

[HTML][HTML] Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation

SR Sinha, Y Haileselassie, LP Nguyen, C Tropini… - Cell host & …, 2020 - cell.com
Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant
on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in …

[HTML][HTML] Metabolism disrupting chemicals and metabolic disorders

JJ Heindel, B Blumberg, M Cave, R Machtinger… - Reproductive …, 2017 - Elsevier
The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …

EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals

AC Gore, VA Chappell, SE Fenton, JA Flaws… - Endocrine …, 2015 - academic.oup.com
Abstract The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to
the scientific community about how environmental endocrine-disrupting chemicals (EDCs) …

Environmental obesogens: mechanisms and controversies

JJ Heindel, B Blumberg - Annual review of pharmacology and …, 2019 - annualreviews.org
Obesity is a worldwide pandemic in adults as well as children and adds greatly to health
care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular …

Metabolic syndrome and associated diseases: from the bench to the clinic

DL Mendrick, AM Diehl, LS Topor… - Toxicological …, 2018 - academic.oup.com
Abstract Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, a
Society of Toxicology Contemporary Concepts in Toxicology (CCT) workshop was held on …

Oxidative stress in NAFLD: role of nutrients and food contaminants

C Rives, A Fougerat, S Ellero-Simatos, N Loiseau… - Biomolecules, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic
syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance …

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

B Wang, EE Tsakiridis, S Zhang, A Llanos… - Nature …, 2021 - nature.com
Obesity results from a caloric imbalance between energy intake, absorption and
expenditure. In both rodents and humans, diet-induced thermogenesis contributes to energy …

[HTML][HTML] Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals

RJ Egusquiza, B Blumberg - Endocrinology, 2020 - academic.oup.com
The incidence of obesity has reached an all-time high, and this increase is observed
worldwide. There is a growing need to understand all the factors that contribute to obesity to …