Airway inflammation in COPD: progress to precision medicine
C Brightling, N Greening - European Respiratory Journal, 2019 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …
The contribution of small airway obstruction to the pathogenesis of chronic obstructive pulmonary disease
The hypothesis that the small conducting airways were the major site of obstruction to airflow
in normal lungs was introduced by Rohrer in 1915 and prevailed until Weibel introduced a …
in normal lungs was introduced by Rohrer in 1915 and prevailed until Weibel introduced a …
[HTML][HTML] Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip
Smoking represents a major risk factor for chronic obstructive pulmonary disease (COPD),
but it is difficult to characterize smoke-induced injury responses under physiological …
but it is difficult to characterize smoke-induced injury responses under physiological …
[HTML][HTML] Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death
worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by …
worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by …
Exhaustion of airway basal progenitor cells in early and established chronic obstructive pulmonary disease
M Ghosh, YE Miller, I Nakachi, JB Kwon… - American journal of …, 2018 - atsjournals.org
Rationale: Up to 40% of smokers develop chronic obstructive pulmonary disease (COPD)
over a period that spans decades. Despite the importance of COPD, much remains to be …
over a period that spans decades. Despite the importance of COPD, much remains to be …
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …
The AGE-RAGE axis and RAGE genetics in chronic obstructive pulmonary disease
A Sharma, S Kaur, M Sarkar, BC Sarin… - Clinical Reviews in …, 2021 - Springer
Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases
limiting the airflow due to narrowing of airways, chronic bronchitis and emphysema that …
limiting the airflow due to narrowing of airways, chronic bronchitis and emphysema that …
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
BW Richmond, RM Brucker, W Han, RH Du… - Nature …, 2016 - nature.com
Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary
disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) …
disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) …
The role of the small airways in the pathophysiology of asthma and chronic obstructive pulmonary disease
Chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease
(COPD), represent a major social and economic burden for worldwide health systems …
(COPD), represent a major social and economic burden for worldwide health systems …
β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction
MQ Mahmood, EH Walters, SD Shukla, S Weston… - Scientific reports, 2017 - nature.com
COPD is characterised by poorly reversible airflow obstruction usually due to cigarette
smoking. The transcription factor clusters of β-catenin/Snail1/Twist has been implicated in …
smoking. The transcription factor clusters of β-catenin/Snail1/Twist has been implicated in …