Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively
used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune …

CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that
interacts directly with astrocytes, neurons and pericytes. It protects the brain from the …

The present review discusses the potential use of solid lipid nanoparticles for brain drug
targeting purposes. The state of the art on surfactant-coated poly (alkylcyanoacrylate) …

Being the most delicate organ of the body, the brain is protected against potentially toxic
substances by the blood-brain barrier (BBB), which restricts the entry of most …

The incidence of dementia is increasing at an alarming rate, and has become a major public
health concern. Alzheimer disease (AD) is the most common form of dementia and is …

Abstract Amyloid-beta (Aβ 1-42) plaques and neurofibrillary tangles (NFTs) are the main
hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD) …

The lactoferrin (Lf) conjugated poly (ethyleneglycol)–poly (lactide) nanoparticle (Lf–NP) was
constructed in this paper as a novel biodegradable brain drug delivery system with …

Central nervous system disorders are already prevalent and steadily increasing among
populations worldwide. However, most of the pharmaceuticals present on world markets are …

Many studies showed that transferrin increases brain delivery of nanoparticles (NPs) in vivo,
however the mechanisms implied in their brain uptake are not yet clearly elucidated. In this …