Inhaled medicines: past, present, and future

S Anderson, P Atkins, P Bäckman, D Cipolla… - Pharmacological …, 2022 - ASPET
The purpose of this review is to summarize essential pharmacological, pharmaceutical, and
clinical aspects in the field of orally inhaled therapies that may help scientists seeking to …

Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes

JM Borghardt, C Kloft, A Sharma - Canadian respiratory journal, 2018 - Wiley Online Library
The inhalation route is frequently used to administer drugs for the management of
respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared …

Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges

P Kumbhar, A Manjappa, R Shah, NK Jha… - Journal of Controlled …, 2022 - Elsevier
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …

Recent advances in inhalable liposomes for treatment of pulmonary diseases: concept to clinical stance

PP Mehta, D Ghoshal, AP Pawar, SS Kadam… - Journal of drug delivery …, 2020 - Elsevier
Liposomes and liposomes-based drug delivery systems are promising carriers in the rapidly
evolving field of nanomedicine. Liposomes are receiving growing attention in the scientific …

Use of computational fluid dynamics deposition modeling in respiratory drug delivery

PW Longest, K Bass, R Dutta, V Rani… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

[HTML][HTML] Targeting inflammation in non-small cell lung cancer through drug repurposing

T Rajasegaran, CW How, A Saud, A Ali, JCW Lim - Pharmaceuticals, 2023 - mdpi.com
Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be
classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers …

[HTML][HTML] Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

AJ Clippinger, D Allen, H Behrsing, KA BéruBé… - Toxicology in vitro, 2018 - Elsevier
New approaches are needed to assess the effects of inhaled substances on human health.
These approaches will be based on mechanisms of toxicity, an understanding of dosimetry …

[HTML][HTML] Additive manufacturing in respiratory sciences–Current applications and future prospects

S Bock, T Rades, J Rantanen, R Scherließ - Advanced Drug Delivery …, 2022 - Elsevier
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of
customised objects with specific attributes. The versatility of AM procedures and constant …

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

A Artzy-Schnirman, N Hobi, N Schneider-Daum… - European Journal of …, 2019 - Elsevier
With rapid advances in micro-fabrication processes and the availability of biologically-
relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for …

Developing inhaled drugs for respiratory diseases: a medicinal chemistry perspective

E Pasqua, N Hamblin, C Edwards, C Baker-Glenn… - Drug Discovery …, 2022 - Elsevier
Despite the devastating impact of many lung diseases on human health, there is still a
significant unmet medical need in respiratory diseases, for which inhaled delivery …