Inhaled medicines: past, present, and future
The purpose of this review is to summarize essential pharmacological, pharmaceutical, and
clinical aspects in the field of orally inhaled therapies that may help scientists seeking to …
clinical aspects in the field of orally inhaled therapies that may help scientists seeking to …
Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes
JM Borghardt, C Kloft, A Sharma - Canadian respiratory journal, 2018 - Wiley Online Library
The inhalation route is frequently used to administer drugs for the management of
respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared …
respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared …
Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …
cancer deaths throughout the world. The shortfall of affordable and effective first-line …
Recent advances in inhalable liposomes for treatment of pulmonary diseases: concept to clinical stance
Liposomes and liposomes-based drug delivery systems are promising carriers in the rapidly
evolving field of nanomedicine. Liposomes are receiving growing attention in the scientific …
evolving field of nanomedicine. Liposomes are receiving growing attention in the scientific …
Use of computational fluid dynamics deposition modeling in respiratory drug delivery
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
[HTML][HTML] Targeting inflammation in non-small cell lung cancer through drug repurposing
Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be
classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers …
classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers …
[HTML][HTML] Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity
AJ Clippinger, D Allen, H Behrsing, KA BéruBé… - Toxicology in vitro, 2018 - Elsevier
New approaches are needed to assess the effects of inhaled substances on human health.
These approaches will be based on mechanisms of toxicity, an understanding of dosimetry …
These approaches will be based on mechanisms of toxicity, an understanding of dosimetry …
[HTML][HTML] Additive manufacturing in respiratory sciences–Current applications and future prospects
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of
customised objects with specific attributes. The versatility of AM procedures and constant …
customised objects with specific attributes. The versatility of AM procedures and constant …
Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline
A Artzy-Schnirman, N Hobi, N Schneider-Daum… - European Journal of …, 2019 - Elsevier
With rapid advances in micro-fabrication processes and the availability of biologically-
relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for …
relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for …
Developing inhaled drugs for respiratory diseases: a medicinal chemistry perspective
E Pasqua, N Hamblin, C Edwards, C Baker-Glenn… - Drug Discovery …, 2022 - Elsevier
Despite the devastating impact of many lung diseases on human health, there is still a
significant unmet medical need in respiratory diseases, for which inhaled delivery …
significant unmet medical need in respiratory diseases, for which inhaled delivery …