RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

[HTML][HTML] Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

LF Dong, J Rohlena, R Zobalova, Z Nahacka… - Journal of Cell …, 2023 - rupress.org
Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

H Scheiblich, C Dansokho, D Mercan, SV Schmidt… - Cell, 2021 - cell.com
Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Tunneling nanotubes provide a route for SARS-CoV-2 spreading

A Pepe, S Pietropaoli, M Vos, G Barba-Spaeth… - Science …, 2022 - science.org
Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection represent a major issue in long coronavirus disease. How SARS-CoV-2 …

Viral and host heterogeneity and their effects on the viral life cycle

JE Jones, V Le Sage, SS Lakdawala - Nature Reviews Microbiology, 2021 - nature.com
Traditionally, the viral replication cycle is envisioned as a single, well-defined loop with four
major steps: attachment and entry into a target cell, replication of the viral genome …

Mitochondria can cross cell boundaries: An overview of the biological relevance, pathophysiological implications and therapeutic perspectives of intercellular …

D Valenti, RA Vacca, L Moro, A Atlante - International journal of molecular …, 2021 - mdpi.com
Mitochondria are complex intracellular organelles traditionally identified as the
powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In …

The functions, methods, and mobility of mitochondrial transfer between cells

Y Qin, X Jiang, Q Yang, J Zhao, Q Zhou… - Frontiers in oncology, 2021 - frontiersin.org
Mitochondria are vital organelles in cells, regulating energy metabolism and apoptosis.
Mitochondrial transcellular transfer plays a crucial role during physiological and pathological …

Key gaps in the knowledge of the porcine respiratory reproductive syndrome virus (PRRSV)

S Montaner-Tarbes, HA Del Portillo… - Frontiers in veterinary …, 2019 - frontiersin.org
The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most
important swine diseases in the world. It is causing an enormous economic burden due to …

HSV-1 cytoplasmic envelopment and egress

I Ahmad, DW Wilson - International journal of molecular sciences, 2020 - mdpi.com
Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …

[HTML][HTML] Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics

Z Payandeh, B Tangruksa, J Synnergren… - Molecular Aspects of …, 2024 - Elsevier
Modern methods of molecular diagnostics and therapy have revolutionized the field of
medicine in recent years by providing more precise and effective tools for detecting and …