[HTML][HTML] Advances in asthma and allergic disease genetics: Is bigger always better?

N Schoettler, E Rodríguez, S Weidinger… - Journal of Allergy and …, 2019 - Elsevier
This review focuses on genome-wide association studies (GWASs) of asthma and allergic
diseases published between January 1, 2018, and June 30, 2019. During this time period …

Pharmacogenetics of asthma

JJ Lima, KV Blake, KG Tantisira… - Current opinion in …, 2009 - journals.lww.com
Identification of novel variants that contribute to response heterogeneity supports future
studies of single nucleotide polymorphism discovery and include gene expression and …

A genome-wide association study of bronchodilator response in Latinos implicates rare variants

KA Drake, DG Torgerson, CR Gignoux… - Journal of allergy and …, 2014 - Elsevier
Background The primary rescue medication to treat acute asthma exacerbation is the short-
acting β 2-adrenergic receptor agonist; however, there is variation in how well a patient …

Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point

ECY Hilton, PG Baverel, A Woodcock… - Journal of allergy and …, 2013 - Elsevier
Background Inhaled capsaicin elicits cough reproducibly in human subjects and is widely
used in the study of cough and antitussive therapies. However, the traditional end points C2 …

A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

ML Spear, D Hu, M Pino-Yanes, S Huntsman… - The …, 2019 - nature.com
Short-acting β2-adrenergic receptor agonists (SABAs) are the most commonly prescribed
asthma medications worldwide. Response to SABAs is measured as bronchodilator drug …

Noninvasive ventilation coupled with nebulization during asthma crises: a randomized controlled trial

VC Galindo-Filho, DC Brandão… - Respiratory …, 2013 - rc.rcjournal.com
BACKGROUND: Despite the clinical improvements attributed to noninvasive ventilation
(NIV) during asthma crises, and the well established effects of nebulization, there are few …

Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness

J Joo, ACY Mak, S Xiao, PM Sleiman, D Hu… - Scientific reports, 2022 - nature.com
Variability in response to short-acting β2-agonists (eg, albuterol) among patients with
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …

Management of acute loss of asthma control in the yellow zone: a practice parameter

C Dinakar, J Oppenheimer, J Portnoy… - Annals of Allergy …, 2014 - annallergy.org
C. Dinakar et al./Ann Allergy Asthma Immunol 113 (2014) 143e159 147 desired properties
(ie, ICS with formoterol) are available in the United States, the FDA has not approved those …

Reduced asthma exacerbations in adult patients treated with bronchial thermoplasty

T Akaba, T Jo, M Iwagami, Y Hashimoto… - The Journal of Allergy …, 2023 - Elsevier
Background Bronchial thermoplasty (BT) has been shown to be effective in randomized
controlled trials of patients with severe asthma who failed to achieve disease control with …

GLCCI1 variation is associated with asthma susceptibility and inhaled corticosteroid response in a Chinese Han population

C Hu, Q Xun, X Li, R He, R Lu, S Zhang, X Hu… - Archives of Medical …, 2016 - Elsevier
Background and Aims GLCCI1 variations are found to be associated with response to
glucocorticoid therapy in non-Hispanic white subjects with asthma. However, there are also …