Advances in organ-on-a-chip engineering

B Zhang, A Korolj, BFL Lai, M Radisic - Nature Reviews Materials, 2018 - nature.com
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

[HTML][HTML] From 3D cell culture to organs-on-chips

D Huh, GA Hamilton, DE Ingber - Trends in cell biology, 2011 - cell.com
3D cell-culture models have recently garnered great attention because they often promote
levels of cell differentiation and tissue organization not possible in conventional 2D culture …

[HTML][HTML] A robot-assisted acoustofluidic end effector

J Durrer, P Agrawal, A Ozgul, SCF Neuhauss… - Nature …, 2022 - nature.com
Liquid manipulation is the foundation of most laboratory processes. For macroscale liquid
handling, both do-it-yourself and commercial robotic systems are available; however, for …

Engineers are from PDMS-land, Biologists are from Polystyrenia

E Berthier, EWK Young, D Beebe - Lab on a Chip, 2012 - pubs.rsc.org
As the integration of microfluidics into cell biology research proceeds at an ever-increasing
pace, a critical question for those working at the interface of both disciplines is which device …

Deep learning with microfluidics for biotechnology

J Riordon, D Sovilj, S Sanner, D Sinton… - Trends in …, 2019 - cell.com
Advances in high-throughput and multiplexed microfluidics have rewarded biotechnology
researchers with vast amounts of data but not necessarily the ability to analyze complex data …

Revisiting lab-on-a-chip technology for drug discovery

P Neužil, S Giselbrecht, K Länge, TJ Huang… - Nature reviews Drug …, 2012 - nature.com
The field of microfluidics or lab-on-a-chip technology aims to improve and extend the
possibilities of bioassays, cell biology and biomedical research based on the idea of …

Recent advances in the use of microfluidic technologies for single cell analysis

TW Murphy, Q Zhang, LB Naler, S Ma, C Lu - Analyst, 2018 - pubs.rsc.org
The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …

Micro total analysis systems for cell biology and biochemical assays

ML Kovarik, PC Gach, DM Ornoff, Y Wang… - Analytical …, 2012 - ACS Publications
Novel applications of micro total analysis systems (μTAS) are addressing fundamental
biological questions, creating new biomedical reagents, and developing innovative cell and …

The RootChip: an integrated microfluidic chip for plant science

G Grossmann, WJ Guo, DW Ehrhardt… - The plant …, 2011 - academic.oup.com
Studying development and physiology of growing roots is challenging due to limitations
regarding cellular and subcellular analysis under controlled environmental conditions. We …

Microfluidic systems for hydrodynamic trapping of cells and clusters

Q Luan, C Macaraniag, J Zhou, I Papautsky - Biomicrofluidics, 2020 - pubs.aip.org
Microfluidic devices have been widely applied to trapping and isolation of cells and clusters
for controllable intercellular environments and high-throughput analysis, triggering …