Next-generation sequencing: insights to advance clinical investigations of the microbiome
CR Wensel, JL Pluznick, SL Salzberg… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …
human microbiome by allowing for the discovery and characterization of unculturable …
Next-generation sequencing technology: current trends and advancements
H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - Biology, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …
research. NGS can sequence millions of DNA fragments at once, providing detailed …
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
CN Spencer, JL McQuade, V Gopalakrishnan… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in
cancer, but the effect of diet and supplements on this interaction is not well studied. We …
cancer, but the effect of diet and supplements on this interaction is not well studied. We …
Grazing and ecosystem service delivery in global drylands
FT Maestre, Y Le Bagousse-Pinguet… - Science, 2022 - science.org
Grazing represents the most extensive use of land worldwide. Yet its impacts on ecosystem
services remain uncertain because pervasive interactions between grazing pressure …
services remain uncertain because pervasive interactions between grazing pressure …
[HTML][HTML] Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
K Hezaveh, RS Shinde, A Klötgen, MJ Halaby… - Immunity, 2022 - cell.com
The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
K Hosomi, M Saito, J Park, H Murakami… - Nature …, 2022 - nature.com
The gut microbiome is an important determinant in various diseases. Here we perform a
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …
Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut
MF Laursen, M Sakanaka, N von Burg, U Mörbe… - Nature …, 2021 - nature.com
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life
immune development, and the gut microbiota can impact host physiology in various ways …
immune development, and the gut microbiota can impact host physiology in various ways …
Aridity-driven shift in biodiversity–soil multifunctionality relationships
W Hu, J Ran, L Dong, Q Du, M Ji, S Yao, Y Sun… - Nature …, 2021 - nature.com
Relationships between biodiversity and multiple ecosystem functions (that is, ecosystem
multifunctionality) are context-dependent. Both plant and soil microbial diversity have been …
multifunctionality) are context-dependent. Both plant and soil microbial diversity have been …
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial
M Reyman, MA Van Houten, RL Watson… - Nature …, 2022 - nature.com
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have
pronounced effects on gut microbiome development and selection of antimicrobial …
pronounced effects on gut microbiome development and selection of antimicrobial …
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …