[HTML][HTML] The IL-17 family of cytokines in psoriasis: IL-17A and beyond

NC Brembilla, L Senra, WH Boehncke - Frontiers in immunology, 2018 - frontiersin.org
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major
global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been …

Psoriasis and the metabolic syndrome

P Gisondi, AC Fostini, I Fossà, G Girolomoni… - Clinics in …, 2018 - Elsevier
Chronic plaque psoriasis is an immune-mediated inflammatory skin disease that is strongly
associated with the clinical features of the metabolic syndrome (MetS), including abdominal …

Sulfoximines as rising stars in modern drug discovery? Current status and perspective on an emerging functional group in medicinal chemistry

P Mäder, L Kattner - Journal of Medicinal Chemistry, 2020 - ACS Publications
Sulfoximines have been largely disregarded in medicinal chemistry for a long time.
However, recently, they have risen to the apparent level of stardom on the drug discovery …

[HTML][HTML] Dendritic cells and macrophages in the pathogenesis of psoriasis

M Kamata, Y Tada - Frontiers in immunology, 2022 - frontiersin.org
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
This disease impairs patients' quality of life enormously. Pathological findings demonstrate …

[HTML][HTML] Efficacy and safety of biologics for psoriasis and psoriatic arthritis and their impact on comorbidities: a literature review

M Kamata, Y Tada - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
It impairs patients' quality of life enormously. It has been recognized not only as a skin …

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

DG McGonagle, IB McInnes, BW Kirkham… - Annals of the …, 2019 - ard.bmj.com
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

EFSA Panel on Food Contact Materials … - EFSA …, 2023 - Wiley Online Library
In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body
weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the …

[HTML][HTML] Adaptive and innate immunity in psoriasis and other inflammatory disorders

MP Schön - Frontiers in immunology, 2019 - frontiersin.org
Over the past three decades, a considerable body of evidence has highlighted T cells as
pivotal culprits in the pathogenesis of psoriasis. This includes the association of psoriasis …

The role of IL‐23 and the IL‐23/TH17 immune axis in the pathogenesis and treatment of psoriasis

G Girolomoni, R Strohal, L Puig… - Journal of the …, 2017 - Wiley Online Library
Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people
worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to …

[HTML][HTML] The interleukin-23/interleukin-17 axis links adaptive and innate immunity in psoriasis

MP Schön, L Erpenbeck - Frontiers in immunology, 2018 - frontiersin.org
Research into the pathophysiology of psoriasis has shed light onto many fascinating
immunological interactions and underlying genetic constellations. Most prominent among …