Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action
Andrographis paniculata has long been part of the traditional herbal medicine system in
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
JCW Lim, TK Chan, DSW Ng… - Clinical and …, 2012 - Wiley Online Library
Andrographis paniculata (Burm. f) Nees, commonly known as 'king of bitters', is a
herbaceous plant belonging to the Family Acanthaceae. It has been widely used for …
herbaceous plant belonging to the Family Acanthaceae. It has been widely used for …
Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in
the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU) …
the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU) …
A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High …
14-Deoxy-11, 12-didehydroandrographolide (deAND), a diterpenoid in Andrographis
paniculata (Burm. f.) Nees, acts as a bioactive phytonutrient that can treat many diseases. To …
paniculata (Burm. f.) Nees, acts as a bioactive phytonutrient that can treat many diseases. To …
Labdane diterpenoids as potential anti-inflammatory agents
QTN Tran, WSF Wong, CLL Chai - Pharmacological research, 2017 - Elsevier
The search for new anti-inflammatory agents is challenging due to the complexity of the
inflammatory process and its role in host defense. Over the past few decades, a significant …
inflammatory process and its role in host defense. Over the past few decades, a significant …
Andrographolide: A natural product template for the generation of structurally and biologically diverse diterpenes
SGS Kandanur, N Tamang, NR Golakoti… - European Journal of …, 2019 - Elsevier
From times immemorial, natural products have played an important role in the management
of human health. Andrographis paniculata, belonging to the family Acanthaceae and its …
of human health. Andrographis paniculata, belonging to the family Acanthaceae and its …
Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process
X Yang, Y Li, Y He, T Li, W Wang, J Zhang, J Wei… - International …, 2015 - Elsevier
Cordycepin (Cor), which is a naturally occurring nucleoside derivative isolated from
Cordyceps militaris, has been shown to exert excellent antiinflammatory activity in a murine …
Cordyceps militaris, has been shown to exert excellent antiinflammatory activity in a murine …
Multi-targeting andrographolide and its natural analogs as potential therapeutic agents
Andrographis paniculata (A. paniculata) is a medicinal plant used in the Indian and Chinese
traditional medicinal systems for its various beneficial properties of therapeutics. This is due …
traditional medicinal systems for its various beneficial properties of therapeutics. This is due …
Rosmarinic acid attenuates airway inflammation and hyperresponsiveness in a murine model of asthma
Z Liang, Y Xu, X Wen, H Nie, T Hu, X Yang, X Chu… - Molecules, 2016 - mdpi.com
Rosmarinic acid (RA) has numerous pharmacologic effects, including anti-oxidant, anti-
inflammatory, and analgesic effects. This study aimed to evaluate the preventive activity of …
inflammatory, and analgesic effects. This study aimed to evaluate the preventive activity of …
14-Deoxy-11, 12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral …
W Cai, Y Li, S Chen, M Wang, A Zhang, H Zhou… - Antiviral Research, 2015 - Elsevier
The highly pathogenic avian influenza H5N1 virus has become a worldwide public health
threat, and current antiviral therapies have limited activity against the emerging, resistant …
threat, and current antiviral therapies have limited activity against the emerging, resistant …