Research in mammalian cell biology often relies on developing in vitro models to enable the
growth of cells in the laboratory to investigate a specific biological mechanism or process …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

Stem cell‐derived kidney organoids contain nephron segments that recapitulate
morphological and functional aspects of the human kidney. However, directed differentiation …

Myofibroblasts are present at the invasion front in colon cancer. In an attempt to understand
their putative proinvasive activity, we have developed an in vitro model. Myofibroblasts …

Branching morphogenesis is the developmental program that builds the ramified epithelial
trees of various organs, including the airways of the lung, the collecting ducts of the kidney …

Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases.
Hepatocyte growth factor (HGF), a ligand for the c-Met receptor tyrosine kinase, has …

ERM (Ezrin–Radixin–Moesin) proteins function as plasma membrane–actin cytoskeleton
linkers and participate in the formation of specialized domains of the plasma membrane. We …

Hepatocyte growth factor/Scatter factor (HGF/SF) is a multifunctional growth factor which can
induce diverse biological events. In vitro, these include scattering, invasion, proliferation and …

Expression of hepatocyte growth factor (HGF) and HGF receptor (HGFR, product of the met
proto-oncogene) mRNA were examined by nonisotopic in situ hybridization in a spectrum of …