Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions
Over three percent of people carry a dominant pathogenic mutation, yet only a fraction of
carriers develop disease (incomplete penetrance), and phenotypes from mutations in the …
carriers develop disease (incomplete penetrance), and phenotypes from mutations in the …
Quantifying higher-order epistasis: beware the chimera
Epistasis, or interactions in which alleles at one locus modify the fitness effects of alleles at
other loci, plays a fundamental role in genetics, protein evolution, and many other areas of …
other loci, plays a fundamental role in genetics, protein evolution, and many other areas of …
Genetic Association Analysis of Phenotypes Jointly Influenced by a Pair of Interacting Organisms
V Katsianos - 2024 - knowledge.uchicago.edu
The virulence of infectious diseases is usually affected by a combination of a host and at
least one pathogen organism. Previous experiments have revealed that combining genetic …
least one pathogen organism. Previous experiments have revealed that combining genetic …
[PDF][PDF] Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions Angela Wei1, 2, 3, 4, Richard Border5, 6, Boyang Fu5 …
VA Arboleda - medrxiv.org
Investigating the sources of variable impact of pathogenic variants in monogenic metabolic
conditions Angela Wei1,2,3,4, Richar Page 1 Investigating the sources of variable impact of …
conditions Angela Wei1,2,3,4, Richar Page 1 Investigating the sources of variable impact of …