Most macrophages generate energy to mount an inflammatory cytokine response by
increased glucose metabolism through intracellular glycolysis. Previous studies have …

A hallmark of COVID-19 is a hyperinflammatory state associated with severity. Monocytes
undergo metabolic reprogramming and produce inflammatory cytokines when stimulated …

Objective It is believed that intestinal recruitment of monocytes from Crohn's Disease (CD)
patients who carry NOD2 risk alleles may repeatedly give rise to recruitment of pathogenic …

Background Glycolytic inhibitor 2-deoxy-d-glucose (2-DG) binds to hexokinase in a non-
competitive manner and phosphoglucose isomerase in a competitive manner, blocking the …

Monocyte exhaustion characterized by immune-suppressive features can develop during
sepsis and contribute to adverse patient outcomes. However, molecular mechanisms …

It is well established that infection with Leishmania alters the host cell's transcriptome. Since
mammalian cells have multiple mechanisms to control gene expression, different molecules …

Background Community-acquired pneumonia (CAP) is responsible for a high morbidity and
mortality worldwide. Monocytes are essential for pathogen recognition and the initiation of …

Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work
has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis …

Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to
determine the expression and function of Tet2 in macrophages upon exposure to …

Background Alterations in platelet function have been implicated in the pathophysiology of
COVID-19 since the beginning of the pandemic. While early reports linked hyperactivated …