The key role of electro-chemical signals in cellular processes had been known for many
years, but more recently the interplay with mechanics has been put in evidence and …

Regeneration of severe bone defects remains an enormous challenge in clinic. Developing
regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome …

Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing
robust cardiovascular tissue engineering strategies, which enable synthetic or biological …

Computational models can shape our understanding of cell and tissue remodelling, from cell
spreading, to active force generation, adhesion, and growth. In this mini-review, we discuss …

Rebuilding the kidney in the context of tissue engineering offers a major challenge as the
organ is structurally complex and has a high variety of specific functions. Recreation of …

Adherent cells are generally able to reorient in response to cyclic strain. In three-
dimensional tissues, however, extracellular collagen can affect this cellular response. In this …

Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation
of electric signals and chemical quantities through them is responsible for their nonlinear …

Commitment of stem cells to different lineages is inherently stochastic but regulated by a
range of environmental bio/chemo/mechanical cues. Here, we develop an integrated …

The myocardium is a mechanically active tissue typified by anisotropy of the resident cells
[cardiomyocytes (CMs) and cardiac fibroblasts (cFBs)] and the extracellular matrix (ECM) …

A simple, transparent, two-dimensional, nonlinear model of cell reorientation is constructed
in this paper. The cells are attached to a substrate by “focal adhesions” that transmit the …