MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either
PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the …

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause
of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report …

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that
promotes fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS). We and …

MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) that typically consist
of 19–25 nucleotides in length. These molecules function as essential regulators of gene …

Renal cysts are the defining feature of autosomal dominant polycystic kidney disease
(ADPKD); however, the substantial interstitial inflammation is an often-overlooked aspect of …

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder, which is
caused by mutations in the PKD1 and PKD2 genes, characterizing by progressive growth of …