Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …

Yes‐associated protein (YAP) has been identified as a key driver for epidermal growth factor
receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance. Inhibition of YAP expression could …

Background Radioresistance is a major factor leading to the failure of radiotherapy and poor
prognosis in tumor patients. Following the application of radiotherapy, the activity of various …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Tumor hypoxia is known to be one of critical reasons that limit the efficacy of cancer
therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen …

Abstract Molybdenum disulfide (MoS2), a typical layered 2D transition metal dichalcogenide,
has received colossal interest in the past few years due to its unique structural …

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …