“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Frailty is a distinctive health state in which the ability of older people to cope with acute
stressors is compromised by an increased vulnerability brought by age-associated declines …

Background White matter hyperintensities (WMH), of presumed vascular origin, are visible
and quantifiable neuroradiological markers of brain parenchymal change. These changes …

Frailty is a common syndrome in older individuals that is associated with poor cognitive
outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to …

INTRODUCTION White matter hyperintensities (WMHs) increase with age and contribute to
cognitive and motor function decline. Energy costs for mobility worsen with age, as the …

Background and objectives: It has been suggested that white matter hyperintensity lesions
(WMHs), which typically progress over time, can also regress, and that this might be …

Background The contribution of cerebral small vessel disease (cSVD) to the pathogenesis of
frailty remains uncertain. We aimed to examine the associations between cSVD with …

Introduction Frailty is a geriatric syndrome frequently associated with executive dysfunction
and white matter hyperintensities (WMH). But the relation between executive dysfunction …

Physical frailty is an age-related clinical syndrome that is associated with multiple adverse
health outcomes, including cognitive impairment and dementia. Recent studies have shown …

Objectives Frailty has been shown to predict adverse outcomes in several diseases. We
aimed to evaluate the associations between frailty profiles, both severity and subtype, and …