Human NK cells: surface receptors, inhibitory checkpoints, and translational applications
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
[HTML][HTML] Control of metastasis by NK cells
The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
Y Lan, D Zhang, C Xu, KW Hance, B Marelli… - Science translational …, 2018 - science.org
Antibodies targeting immune checkpoints are emerging as potent and viable cancer
therapies, but not all patients respond to these as single agents. Concurrently targeting …
therapies, but not all patients respond to these as single agents. Concurrently targeting …
Immune checkpoints and their inhibition in cancer and infectious diseases
The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
The mechanism of anti–PD-L1 antibody efficacy against PD-L1–negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector
Blockade of PD-L1 expression on tumor cells via anti–PD-L1 monoclonal antibody (mAb)
has shown great promise for successful cancer treatment by overcoming T-cell exhaustion; …
has shown great promise for successful cancer treatment by overcoming T-cell exhaustion; …
[HTML][HTML] Dysfunction of natural killer cells by FBP1-induced inhibition of glycolysis during lung cancer progression
J Cong, X Wang, X Zheng, D Wang, B Fu, R Sun… - Cell metabolism, 2018 - cell.com
Natural killer (NK) cells are effector lymphocytes with pivotal roles in the resistance against
various tumors; dysfunction of NK cells often results in advanced tumor progression. Tumors …
various tumors; dysfunction of NK cells often results in advanced tumor progression. Tumors …
[HTML][HTML] Innate immune signaling and regulation in cancer immunotherapy
L Corrales, V Matson, B Flood, S Spranger… - Cell research, 2017 - nature.com
A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …
predictive for response to contemporary cancer immunotherapies. The generation of a …
[HTML][HTML] The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
N-linked glycosylation is one of the most abundant posttranslational modifications of
membrane-bound proteins in eukaryotes and affects a number of biological activities …
membrane-bound proteins in eukaryotes and affects a number of biological activities …
[HTML][HTML] The immune checkpoint PD-1 in natural killer cells: expression, function and targeting in tumour immunotherapy
Simple Summary Natural killer cells are innate cytotoxic lymphocytes that play a key role in
the anti-tumor immune response. In the tumor microenvironment, however, the effector …
the anti-tumor immune response. In the tumor microenvironment, however, the effector …
[HTML][HTML] Are conventional type 1 dendritic cells critical for protective antitumor immunity and how?
Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to
orchestrate their expansion, functional polarization and effector activity in non-lymphoid …
orchestrate their expansion, functional polarization and effector activity in non-lymphoid …