Oncolytic viruses: a new class of immunotherapy drugs
HL Kaufman, FJ Kohlhapp, A Zloza - Nature reviews Drug discovery, 2015 - nature.com
Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …
responses through a dual mechanism of action that is dependent on selective tumour cell …
Multiple functions of BCL-2 family proteins
JM Hardwick, L Soane - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …
family of interacting partners includes inhibitors and inducers of cell death. Together they …
Apoptosis in the pathogenesis and treatment of disease
CB Thompson - Science, 1995 - science.org
In multicellular organisms, homeostasis is maintained through a balance between cell
proliferation and cell death. Although much is known about the control of cell proliferation …
proliferation and cell death. Although much is known about the control of cell proliferation …
Disruption of epithelial cell-matrix interactions induces apoptosis
SM Frisch, H Francis - The Journal of cell biology, 1994 - rupress.org
Cell-matrix interactions have major effects upon phenotypic features such as gene
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …
Apoptosis in cancer
SW Lowe, AW Lin - Carcinogenesis, 2000 - academic.oup.com
In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …
understanding of cancer biology and cancer genetics. Among the most important of these …
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
J Zhang, PA Ney - Cell Death & Differentiation, 2009 - nature.com
BNIP3 and NIX are proteins related to the BH3-only family, which induce both cell death and
autophagy. Consistent with their ability to induce cell death, BNIP3 and NIX are implicated in …
autophagy. Consistent with their ability to induce cell death, BNIP3 and NIX are implicated in …
Cell cycle control and cancer
LH Hartwell, MB Kastan - Science, 1994 - science.org
Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
SW Lowe, HE Ruley, T Jacks, DE Housman - Cell, 1993 - cell.com
Although the primary cellular targets of many anticancer agents have been identified, less is
known about the processes leading to the selective cell death of cancer cells or the …
known about the processes leading to the selective cell death of cancer cells or the …
WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis
The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to
be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to …
be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to …
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.
E Rouvier, MF Luciani, MG Mattei… - … (Baltimore, Md.: 1950 …, 1993 - journals.aai.org
To detect novel molecules involved in immune functions, a subtracted cDNA library between
closely related murine lymphoid cells was prepared using improved technology. Differential …
closely related murine lymphoid cells was prepared using improved technology. Differential …