Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

In multicellular organisms, homeostasis is maintained through a balance between cell
proliferation and cell death. Although much is known about the control of cell proliferation …

Cell-matrix interactions have major effects upon phenotypic features such as gene
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …

In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

BNIP3 and NIX are proteins related to the BH3-only family, which induce both cell death and
autophagy. Consistent with their ability to induce cell death, BNIP3 and NIX are implicated in …

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …

Although the primary cellular targets of many anticancer agents have been identified, less is
known about the processes leading to the selective cell death of cancer cells or the …

The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to
be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to …

To detect novel molecules involved in immune functions, a subtracted cDNA library between
closely related murine lymphoid cells was prepared using improved technology. Differential …