Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology
that has revolutionized the way we conceive immunotherapy. The impressive clinical results …

Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

CD19-specific chimeric antigen receptor (CAR19) T-cells effectively induce remission of B-
cell malignancy, but the cost and complexity of production using viral vectors is a factor …

Multiple myeloma (MM) is a plasma cell malignancy that affects an increasing number of
patients worldwide. Despite all the efforts to understand its pathogenesis and develop new …

Genetically engineered T cells have sparked interest in advanced cancer treatment,
reaching a milestone in 2017 with two FDA-approvals for CD19-directed chimeric antigen …

High-Grade Gliomas (HGG) are among the deadliest malignant tumors of central nervous
system (CNS) in pediatrics. Despite aggressive multimodal treatment-including surgical …

Chimeric antigen receptor T (CAR-T) cells have achieved breakthrough efficacies against
hematological malignancies, but their unsatisfactory efficacies in solid tumors limit their …

Successful gene therapies rely on methods that safely introduce DNA into target cells and
enable subsequent expression of proteins. To that end, peptides are an attractive materials …

Traditional bacterial fermentation techniques used to manufacture plasmid are time-
consuming, expensive, and inherently unstable. The production of sufficient GMP grade …

Mobile genetic elements have been harnessed for gene transfer for a wide variety of
applications including generation of stable cell lines, recombinant protein production …