Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused
by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic …

Progressive multifocal leukoencephalopathy is caused by the JC polyomavirus (JCV) and is
one of the most feared complications of HIV-1 infection. Unlike other opportunistic infections …

Cases of PML should be evaluated according to predisposing factors, as these subgroups
differ by incidence rate, clinical course, and prognosis. The three most significant groups at …

We describe progressive multifocal leukoencephalopathy (PML) caused by infection with
human polyomavirus JC virus in a patient with multiple sclerosis who was treated with …

Since its initial description, there have been significant changes in the epidemiology,
pathogenesis, and clinical and imaging manifestations of JCV infection of brain. The most …

Background: We sought to characterize the role of immunologic, virologic, and radiologic
determinants of survival in patients with progressive multifocal leukoencephalopathy (PML) …

Background. We investigated the incidence and outcome of progressive multifocal
leukoencephalopathy (PML) in human immunodeficiency virus (HIV)–infected individuals …

The immune reconstitution inflammatory syndrome (IRIS) is a frequent early complication of
antiretroviral therapy (ART) in patients with advanced HIV. Because there is no confirmatory …

Natalizumab (Tysabri) was the first monoclonal antibody approved for the treatment of
relapsing forms of multiple sclerosis (MS). After its initial approval, 3 patients undergoing …

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by
reactivation of JC virus in immunosuppressed patients. The diagnosis is usually suggested …