Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion
The brain is well protected against microbial invasion by cellular barriers, such as the blood-
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …
The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens
D Serruto, MJ Bottomley, S Ram, MM Giuliani… - Vaccine, 2012 - Elsevier
Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …
devastating septicemia. Although effective vaccines exist for several serogroups of …
Review of meningococcal group B vaccines
DM Granoff - Clinical infectious diseases, 2010 - academic.oup.com
No broadly effective vaccines are available for prevention of group B meningococcal
disease, which accounts for> 50% of all cases. The group B capsule is an autoantigen and …
disease, which accounts for> 50% of all cases. The group B capsule is an autoantigen and …
Vaccines, reverse vaccinology, and bacterial pathogenesis
I Delany, R Rappuoli, KL Seib - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Advances in genomics and innovative strategies such as reverse vaccinology have changed
the concepts and approaches to vaccine candidate selection and design. Genome mining …
the concepts and approaches to vaccine candidate selection and design. Genome mining …
The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement
LA Lewis, J Ngampasutadol, R Wallace… - PLoS …, 2010 - journals.plos.org
Complement forms an important arm of innate immunity against invasive meningococcal
infections. Binding of the alternative complement pathway inhibitor factor H (fH) to fH-binding …
infections. Binding of the alternative complement pathway inhibitor factor H (fH) to fH-binding …
Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease
LK McNeil, RJ Zagursky, SL Lin, E Murphy… - Microbiology and …, 2013 - Am Soc Microbiol
Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …
and can cause devastating invasive disease. Although capsular polysaccharide-based …
[HTML][HTML] Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain …
G Frosi, A Biolchi, ML Sapio, F Rigat, S Gilchrist… - Vaccine, 2013 - Elsevier
Abstract Background 4CMenB (Bexsero), a vaccine developed against invasive
meningococcal disease caused by capsular group B strains (MenB), was recently licensed …
meningococcal disease caused by capsular group B strains (MenB), was recently licensed …
Transcriptome Analysis of Neisseria meningitidis in Human Whole Blood and Mutagenesis Studies Identify Virulence Factors Involved in Blood …
H Echenique-Rivera, A Muzzi, E Del Tordello… - PLoS …, 2011 - journals.plos.org
During infection Neisseria meningitidis (Nm) encounters multiple environments within the
host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the …
host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the …
Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen
E Malito, A Faleri, P Lo Surdo… - Proceedings of the …, 2013 - National Acad Sciences
Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for
understanding the nature of immune responses and designing improved vaccines …
understanding the nature of immune responses and designing improved vaccines …
The key role of genomics in modern vaccine and drug design for emerging infectious diseases
It can be argued that the arrival of the “genomics era” has significantly shifted the paradigm
of vaccine and therapeutics development from microbiological to sequence-based …
of vaccine and therapeutics development from microbiological to sequence-based …