Obesity and bone: a complex relationship

G Rinonapoli, V Pace, C Ruggiero, P Ceccarini… - International journal of …, 2021 - mdpi.com
There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …

Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity

KH Collins, W Herzog, GZ MacDonald… - Frontiers in …, 2018 - frontiersin.org
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

[HTML][HTML] M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

Y Wang, Q Lin, H Zhang, S Wang, J Cui, Y Hu, J Liu… - Bioactive materials, 2023 - Elsevier
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture
healing. Macrophages play a key role in the process of fracture healing by undergoing …

Obesity and bone health: a complex link

J Hou, C He, W He, M Yang, X Luo, C Li - Frontiers in cell and …, 2020 - frontiersin.org
So far, the connections between obesity and skeleton have been extensively explored, but
the results are inconsistent. Obesity is thought to affect bone health through a variety of …

Osteometabolism: metabolic alterations in bone pathologies

RK Srivastava, L Sapra, PK Mishra - Cells, 2022 - mdpi.com
Renewing interest in the study of intermediate metabolism and cellular bioenergetics is
brought on by the global increase in the prevalence of metabolic illnesses. Understanding of …

The impact of type 2 diabetes on bone fracture healing

C Marin, FP Luyten, B Van der Schueren… - Frontiers in …, 2018 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of
elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a …

Bone marrow adipose tissue: to be or not to be a typical adipose tissue?

P Hardouin, T Rharass, S Lucas - Frontiers in endocrinology, 2016 - frontiersin.org
Bone marrow adipose tissue (BMAT) emerges as a distinct fat depot whose importance has
been proved in the bone–fat interaction. Indeed, it is well recognized that adipokines and …

Dual effects of lipid metabolism on osteoblast function

NS Alekos, MC Moorer, RC Riddle - Frontiers in Endocrinology, 2020 - frontiersin.org
The skeleton is a dynamic and metabolically active organ with the capacity to influence
whole body metabolism. This newly recognized function has propagated interest in the …

Cellular and molecular mechanisms associating obesity to bone loss

YS Forte, M Renovato-Martins, C Barja-Fidalgo - Cells, 2023 - mdpi.com
Obesity is an alarming disease that favors the upset of other illnesses and enhances
mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The …

eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice

J Li, X Li, D Liu, K Hamamura, Q Wan, S Na… - Cell Death & …, 2019 - nature.com
Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-
forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that …