Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …

Abstract Type-2 Diabetes (T2D) is characterized by insulin resistance and accompanied by
psychiatric comorbidities including major depressive disorders (MDD). Patients with T2D are …

In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

We set out to determine whether machine learning–based algorithms that included
functionally validated pharmacogenomic biomarkers joined with clinical measures could …

Abstract The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by
regulating extracellular brain serotonin levels; it remains unclear to what extent 5-HTT levels …

Major depressive disorder is a growing and poorly understood pathology. Due to technical
and ethical limitations, a significant proportion of the research on depressive disorders …

Major depressive disorder (MDD) is a highly prevalent mental illness whose therapy
management remains uncertain, with more than 20% of patients who do not achieve …

Major depressive disorder (MDD) is a psychiatric disorder that affects a large portion of the
population, with dysregulation of the serotonergic system, which is deeply involved in both …