The mammary gland develops through several distinct stages. The first transpires in the
embryo as the ectoderm forms a mammary line that resolves into placodes. Regulated by …

Mammary gland development occurs through distinctive stages throughout embryonic and
pubertal development and reproductive life. At each stage, different signals are required to …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

The vertebrate limb with its complex anatomy develops from a small bud of undifferentiated
mesoderm cells encased in ectoderm. The bud has its own intrinsic polarity and can develop …

TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

The mammary gland is an epidermal appendage that begins to form during embryogenesis,
but whose development is only completed during pregnancy. Each mammary gland begins …

Abstract β-Catenin plays important roles in mammary development and tumorigenesis
through its functions in cell adhesion, signal transduction and regulation of cell-context …

Embryonic mammary gland development involves the formation of mammary placodes,
invagination of flask-shaped mammary buds and development of miniature bi-layered ductal …

Mammary glands become functional only in adult life but their development starts in the
embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short …

A cancer cell-centric view has long dominated the field of cancer biology. Research efforts
have focussed on aberrant cancer cell signalling pathways and on changes to cancer cell …