Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Sleep duration, psychiatric disorders and dementias are closely interconnected in older
adults. However, the underlying genetic mechanisms and brain structural changes are …

A primary goal of neuroscience is to understand the relationship between the brain and
behavior. While magnetic resonance imaging (MRI) examines brain structure and function …

A good quality and amount of sleep are fundamental to preserve cognition and affect. New
evidence also indicates that poor sleep is detrimental to brain myelination. In this study, we …

Abstract Study Objectives This study assessed the associations between sleep behaviors
with white matter macro and microstructure. Methods A total of 26 354 participants in the UK …

Sleep has been hypothesised to facilitate waste clearance from the brain. We aimed to
determine whether sleep is associated with perivascular spaces on brain magnetic …

Abstract Study Objectives Sleep disturbance is common among midlife women. Poor self-
reported sleep characteristics have been linked to cerebrovascular disease and dementia …

Highlights•Sleep-wake regulation plays a role for cognitive and brain fitness at older
age.•Sleep and rest-activity fragmentation are associated with local and diffuse structural …

Background Hypertension-related illnesses are a leading cause of disability and death in
the United States, where hypertension prevalence in adults is 46%, with only half of those …

Sleep disturbance is a recognized risk factor for Alzheimer's disease (AD), but the
underlying micro-pathological evidence remains limited. To bridge this gap, we established …