The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of
intracellular and extracellular functions through regulating calcium balance, cell apoptosis …

The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand
pattern recognition receptor capable of binding to a range of structurally diverse ligands …

The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although
extensive strides have been made in the treatments for non-diabetic atherosclerosis and its …

The S100 protein family consists of 24 members functionally distributed into three main
subgroups: those that only exert intracellular regulatory effects, those with intracellular and …

The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …