Rational design strategies for nanozymes

Z Chen, Y Yu, Y Gao, Z Zhu - ACS nano, 2023 - ACS Publications
Nanozymes constitute an emerging class of nanomaterials with enzyme-like characteristics.
Over the past 15 years, more than 1200 nanozymes have been developed, and they have …

Biosystem‐inspired engineering of nanozymes for biomedical applications

L Zhang, H Wang, X Qu - Advanced Materials, 2024 - Wiley Online Library
Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to
become surrogates of natural enzymes in many fields by virtue of their advantages of high …

Dimensionality engineering of single-atom nanozyme for efficient peroxidase-mimicking

G Li, H Liu, T Hu, F Pu, J Ren, X Qu - Journal of the American …, 2023 - ACS Publications
In nature, enzymatic reactions occur in well-functioning catalytic pockets, where substrates
bind and react by properly arranging the catalytic sites and amino acids in a three …

Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

C Peng, R Pang, J Li, E Wang - Advanced Materials, 2024 - Wiley Online Library
Nanozymes, a class of nanomaterials mimicking the function of enzymes, have aroused
much attention as the candidate in diverse fields with the arbitrarily tunable features owing to …

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

W Xu, Y Wu, W Gu, D Du, Y Lin, C Zhu - Chemical Society Reviews, 2024 - pubs.rsc.org
Natural metalloenzymes with astonishing reaction activity and specificity underpin essential
life transformations. Nevertheless, enzymes only operate under mild conditions to keep …

Enzyme‐encapsulated protein trap engineered metal–organic framework‐derived biomineral probes for non‐invasive prostate cancer surveillance

Z Yu, J Tang, H Gong, Y Gao, Y Zeng… - Advanced Functional …, 2023 - Wiley Online Library
A paper‐based naked‐eye recognition assay with enzyme‐encapsulated protein
engineered metal–organic framework‐derived biominerals is developed for direct …

Transition Metal High‐Entropy Nanozyme: Multi‐Site Orbital Coupling Modulated High‐Efficiency Peroxidase Mimics

J Feng, X Yang, T Du, L Zhang, P Zhang… - Advanced …, 2023 - Wiley Online Library
Strong substrate affinity and high catalytic efficiency are persistently pursued to generate
high‐performance nanozymes. Herein, with unique surface atomic configurations and …

Employing Noble Metal–Porphyrins to Engineer Robust and Highly Active Single‐Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma

D Wang, J Wang, XJ Gao, H Ding, M Yang… - Advanced …, 2024 - Wiley Online Library
Single‐atom nanozymes (SANzymes) emerge as promising alternatives to conventional
enzymes. However, chemical instability limits their application. Here, a systematic synthesis …

Insight into Iron Leaching from an Ascorbate‐Oxidase‐like Fe− N− C Nanozyme and Oxygen Reduction Selectivity

X Cao, C Zhu, Q Hong, X Chen, K Wang… - Angewandte …, 2023 - Wiley Online Library
Ascorbate (H2A) is a well‐known antioxidant to protect cellular components from free radical
damage and has also emerged as a pro‐oxidant in cancer therapies. However, such …

Modulating the Coordination Environment of Carbon‐Dot‐Supported Fe Single‐Atom Nanozymes for Enhanced Tumor Therapy

Y Han, K Ge, Y Zhao, M Bottini, D Fan, W Wu, L Li… - Small, 2024 - Wiley Online Library
Abstract Herein, carbon dot (CD)‐supported Fe single‐atom nanozymes with high content of
pyrrolic N and ultrasmall size (ph‐CDs‐Fe SAzyme) are fabricated by a phenanthroline …