The search of effective anti-stroke neuroprotectors requires various stroke models adequate
for different aspects of the ischemic processes. The photothrombotic stroke model is …

Stroke is a central nervous system disease that seriously affects people's quality of life and
has the second highest rate of morbidity and mortality in the world. At present, clinical …

Background Systemic inflammation driven neuroinflammation is an event which correlates
with pathogenesis of several neurodegenerative diseases. Therefore, targeting peripheral …

Background/Aims: Calcium-permeable ionotropic NMDAR-mediated hyperactivity is
regarded as the critical factor in modulating the development of ischaemic stroke. Recently …

Uncaria sinensis (US) has long been used as a traditional Korean medicine to treat
cardiovascular and central nervous system diseases, including hypertension and cerebral …

Calpain, a key member of the Calpain cysteine protease superfamily, performs limited
protein hydrolysis in a calcium-dependent manner. Its activity is tightly regulated due to the …

Background. As one of the first steps in the pathology of cerebral ischemia, glutamate‐
induced excitotoxicity progresses too fast to be the target of postischemic intervention …

Developing new treatment strategies for acute ischemic stroke in the last twenty years has
offered some important successes, but also several failures. Most trials of neuroprotective …

Recent preclinical and clinical reports suggest that cerebrolysin shows neuroprotective
properties similar to endogenous neurotrophic factors in neurodegenerative disorders …

Background Dapsone prevents ischemic injury, inhibits apoptosis and shows functional
improvement post-ischemia. However, its effect on proapoptotic or survival proteins in …