Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

Geographic atrophy is a blinding form of age-related macular degeneration characterized by
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …

Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that
depend on the tissue analyzed. Retinal lipofuscin is unique in that it contains mostly lipids …

Fundus autofluorescence (FAF) imaging is an in vivo imaging method that allows for
topographic mapping of naturally or pathologically occurring intrinsic fluorophores of the …

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
older population. Classical hallmarks of early and intermediate AMD are accumulation of …

Purpose To examine whether slowed rod-mediated dark adaptation (DA) in adults with
normal macular health at baseline is associated with the incidence of age-related macular …

Purpose: By optical coherence tomography (OCT) imaging, hyperreflective foci (HRF)
indicate progression risk for advanced age-related macular degeneration (AMD) and are in …

Purpose: To summarize and contextualize recent histology and clinical imaging publications
on retinal pigment epithelium (RPE) fate in advanced age-related macular degeneration …