[HTML][HTML] The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana

R Eggers, A Jammer, S Jha, B Kerschbaumer… - Phytochemistry, 2021 - Elsevier
Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are utilized as
coenzymes in many biochemical reduction-oxidation reactions owing to the ability of the …

[HTML][HTML] Molecular mechanism of metabolic NAD (P) H-dependent electron-transfer systems: The role of redox cofactors

T Iyanagi - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2019 - Elsevier
Abstract NAD (P) H-dependent electron-transfer (ET) systems require three functional
components: a flavin-containing NAD (P) H-dehydrogenase, one-electron carrier and metal …

Structural basis for plant lutein biosynthesis from α-carotene

G Niu, Q Guo, J Wang, S Zhao… - Proceedings of the …, 2020 - National Acad Sciences
Two cytochrome P450 enzymes, CYP97A3 and CYP97C1, catalyze hydroxylations of the β-
and ε-rings of α-carotene to produce lutein. Chirality is introduced at the C-3 atom of both …

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1

LB Tulloch, M Tinti, RJ Wall, SK Weidt… - PLoS …, 2024 - journals.plos.org
Liposomal amphotericin B is an important frontline drug for the treatment of visceral
leishmaniasis, a neglected disease of poverty. The mechanism of action of amphotericin B …

The Phytotoxin Myrigalone A Triggers a Phased Detoxification Programme and Inhibits Lepidium sativum Seed Germination via Multiple Mechanisms including …

K Nakabayashi, M Walker, D Irwin, J Cohn… - International Journal of …, 2022 - mdpi.com
Molecular responses of plants to natural phytotoxins comprise more general and compound-
specific mechanisms. How phytotoxic chalcones and other flavonoids inhibit seedling …

Production of phenylpropanoids and flavonolignans from glycerol by metabolically engineered Escherichia coli

SY Park, D Yang, SH Ha, SY Lee - Biotechnology and …, 2022 - Wiley Online Library
Phenylpropanoids are a group of plant natural products with medicinal importance derived
from aromatic amino acids. Here, we report the production of two representative …

Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis

AC Ebrecht, N van der Bergh, STL Harrison, MS Smit… - Scientific Reports, 2019 - nature.com
Cytochrome P450 reductases (CPRs) are diflavin oxidoreductases that supply electrons to
type II cytochrome P450 monooxygenases (CYPs). In addition, it can also reduce other …

NADPH–Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin

TX Jing, Y Tan, BY Ding, W Dou, DD Wei… - Frontiers in …, 2018 - frontiersin.org
NADPH-cytochrome P450 reductase (CPR) plays an essential role in the cytochrome P450
enzyme system, which aids in the metabolism of endogenous and exogenous compounds …

Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

K Bavishi, D Li, S Eiersholt, EN Hooley, TC Petersen… - Scientific reports, 2018 - nature.com
Cytochrome P450 oxidoreductase (POR) is the primary electron donor in eukaryotic
cytochrome P450 (CYP) containing systems. A wealth of ensemble biophysical studies of …

Functional and structural insight into the flexibility of cytochrome P450 reductases from Sorghum bicolor and its implications for lignin composition

B Zhang, GR Munske, VI Timokhin, J Ralph… - Journal of Biological …, 2022 - ASBMB
Plant NADPH-dependent cytochrome P450 reductase (CPR) is a multidomain enzyme that
donates electrons for hydroxylation reactions catalyzed by class II cytochrome P450 …