Hepatic inflammatory responses in liver fibrosis

L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Fibrosis: from mechanisms to medicines

NC Henderson, F Rieder, TA Wynn - Nature, 2020 - nature.com
Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Molecular and cellular mechanisms of liver fibrosis and its regression

T Kisseleva, D Brenner - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

Liver inflammation and fibrosis

Y Koyama, DA Brenner - The Journal of clinical …, 2017 - Am Soc Clin Investig
Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of
death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and …

[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

JMGR de Morales, L Puig, E Daudén, JD Cañete… - Autoimmunity …, 2020 - Elsevier
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

Inflammatory pathways in alcoholic steatohepatitis

B Gao, MF Ahmad, LE Nagy, H Tsukamoto - Journal of hepatology, 2019 - Elsevier
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

[HTML][HTML] Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance

A Albillos, M Lario, M Álvarez-Mon - Journal of hepatology, 2014 - Elsevier
The term cirrhosis-associated immune dysfunction refers to the main syndromic
abnormalities of immune function, immunodeficiency and systemic inflammation that are …

[HTML][HTML] Pathogenesis of alcoholic liver disease: role of oxidative metabolism

E Ceni, T Mello, A Galli - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular …

Alcoholic liver disease: pathogenesis and new therapeutic targets

B Gao, R Bataller - Gastroenterology, 2011 - Elsevier
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can
lead to fibrosis and cirrhosis. The latest surveillance report published by the National …