Covering: 2015 up to the end of 2020 Even in the golden age of NMR, the number of natural
products being incorrectly assigned is becoming larger every day. The use of quantum NMR …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

The bioconjugation of proteins—that is, the creation of a covalent link between a protein and
any other molecule—has been studied for decades, partly because of the numerous …

One-pot multicomponent coupling of different units in a chemoselective manner and their
late-stage diversification has wide applicability in varying chemistry fields. Here, we report a …

Peptide stapling is a robust strategy for generating enzymatically stable, macrocyclic
peptides. The incorporation of biologically relevant tags (such as cell‐penetrating motifs or …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Numerous strategies for linking desired chemical probes with target peptides and proteins
have been developed and applied in the field of biological chemistry. Approaches for site …

Protein bioconjugates are in high demand for applications in biomedicine, diagnostics,
chemical biology and bionanotechnology. Proteins are large and sensitive molecules …

We report a chemoselective, site-selective, and modular technology for precision
engineering of high-frequency lysine residues in native proteins. It enables a unique …

This article presents a comprehensive overview of multicomponent reactions (MCRs) that
proceed via ortho‐quinone methide intermediates (o‐QM) generated in the reaction …