Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …

Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer
treatment. Due to the low immunogenicity and immune suppression state in the tumor …

BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced
age is one of the critical risk factors for female-related infertility. It is well known that maternal …

Abstract As coronavirus disease 2019 (COVID-19) and aging are both accompanied by
cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures …

Aging is characterized by a progressive loss of tissue and organ function due to genetic and
environmental factors, nutrition, and lifestyle. Oxidative stress is one the most important …