The role of mitochondria spans from the regulation of the oxidative phosphorylation, cell
metabolism and survival/death pathways to a more recently identified function in chronic …

Allergic reactions are highly prevalent pathologies initiated by the production of IgE
antibodies against harmless antigens (allergens) and the activation of the high-affinity IgE …

cAMP response element binding protein (CREB) functions as a prototypical stimulus-
inducible transcription factor (TF) that initiates multiple cellular changes in response to …

Mast cells (MCs) are key effector cells in allergic and inflammatory diseases, and the
SCF/KIT axis regulates most aspects of the cells' biology. Using terminally differentiated skin …

The mechanisms of ovarian endometrioid cyst formation, or cystic ovarian endometriosis,
still remain to be elucidated. To address this issue, we analyzed the involvement of mast cell …

Background Antigenic stimulation through cross-linking the IgE receptor and epithelial cell-
derived cytokine IL-33 are potent stimuli of mast cell (MC) activation. Moreover, IL-33 primes …

Gut microbes are immunologically tolerated in the gastrointestinal tract but trigger
aggressive immune responses upon translocation across the gut barrier. Although oral …

Studies of mast cell biology are dependent on relevant and validated in vitro models. Here,
we present detailed information concerning the phenotype of both freshly isolated human …

Skin mast cells (MCs) mediate acute allergic reactions in the cutaneous environment and
contribute to chronic dermatoses, including urticaria, and atopic or contact dermatitis. The …

Mast cells (MCs) are key effector cells in allergic and inflammatory diseases, and the
SCF/KIT axis regulates most aspects of the cells' biology. Using terminally differentiated skin …