Formulation and characterization of liposomes containing drug absorption enhancers for optimized anti-HIV and antimalarial drug delivery

PS Kheoane, GMA Enslin, C Tarirai - Drug Delivery and Translational …, 2023 - Springer
Most of the current clinically used anti-HIV and antimalarial drugs have low bioavailability,
either due to poor solubility and permeability, rapid clearance from anatomical reservoirs …

[HTML][HTML] Can rooibos (Aspalathus linearis) tea have an effect on conventional antimicrobial therapies?

Z Hübsch, SF Van Vuuren, RL Van Zyl - South African Journal of Botany, 2014 - Elsevier
One of the most commonly consumed and commercially relevant herbal teas in South Africa
is rooibos tea, prepared from the plant, Aspalathus linearis (Burm. F.) Dahlg. In orthodox …

Lipid-lowering effect and oral transport characteristics study of curculigoside

A Wang, J Ning, L Zhao, R Xu - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Introduction The incidence of metabolic disorders during pregnancy is increasing year by
year, with diseases including hypertension and hyperlipidemia. Statins are the primary …

Transepithelial transport of PAMAM dendrimers across isolated rat jejunal mucosae in ussing chambers

D Hubbard, H Ghandehari, DJ Brayden - Biomacromolecules, 2014 - ACS Publications
Oral delivery remains a challenge for poorly permeable hydrophilic macromolecules. Poly
(amido amine)(PAMAM) dendrimers have shown potential for their possible oral delivery …

Regional morphology and transport of PAMAM dendrimers across isolated rat intestinal tissue

D Hubbard, T Bond… - Macromolecular …, 2015 - Wiley Online Library
Intestinal permeability of PAMAM dendrimers has been observed, giving rationale for their
use in oral drug delivery as potential carriers of associated molecules. This study assessed …

[PDF][PDF] Antioxidant and prebiotic activity of selected edible wild plant extracts

PS Kheoane, C Tarirai, TH Gadaga, L Carmen… - 2016 - pdfs.semanticscholar.org
Edible wild plants were investigated as potential sources of antioxidants and prebiotics to
benefit human health. Antioxidant activity, ascorbic acid and total dietary fibre contents were …

Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models

PS Kheoane, GMA Enslin, C Tarirai - European Journal of Pharmaceutical …, 2021 - Elsevier
Background Achievement of an effective concentration of the pharmaceutically active
ingredient in the blood and/or at the target site is an important aspect in the formulation of …

Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers

J Heyns, C Willers, RK Haynes, HN Wong… - Current Drug …, 2018 - ingentaconnect.com
Background: Malaria continues to be a major health concern and affects more than 200
million people a year. Drugs currently used for treatment of malaria are increasingly …

Harnessing herb-drug interactions for enhanced oral delivery of anti-HIV and antimalarial drugs using colloidal formulations

PS Kheoane - 2020 - repository.tml.nul.ls
Problem: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)
and malaria infect and kill a large population globally. Most of the current clinically used anti …