RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

As the up-and-comer in the development of RNA nanotechnology, RNA nanomaterials
based on functionalized rolling circle transcription (RCT) have become promising carriers for …

CRISPR-Cas13a holds enormous potential for developing precise RNA editing. However,
spatial manipulation of CRISPR-Cas13a activity remains a daunting challenge for …

Advances in the DNA nanotechnology have enabled the fabrication of DNA-based
hydrogels with precisely controlled structures and tunable mechanical and biological …

A novel modified nucleic acid nanoparticle harboring an annexin A2 aptamer for ovarian
cancer cell targeting and a GC rich sequence for doxorubicin loading is designed and …

Recently, oligonucleotides have attracted substantial attention in the field of cancer therapy
due to their target specificity and ability to modulate various molecular pathways. However …

The concept of RNA interference therapeutics has been initiated 18 years ago, and the main
bottleneck for translation of the technology into therapeutic products remains the delivery of …

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein-9
nuclease (Cas9) can be used for the specific disruption of a target gene to permanently …

As ribonucleic acid (RNA) nanotechnology has advanced, it has been applied widely in
RNA‐based therapeutics. Among the range of approaches, enzymatically synthesized RNA …

Nucleic acid-based technologies have been applied to numerous biomedical applications.
As a novel material for target detection, DNA has been used to construct a barcode system …