Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …

Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key
functions in a wide array of biological systems. While the role of NF-κB in processes, such as …

Unleashing the immune system with immune checkpoint inhibitors (ICI) has significantly
improved overall survival for subsets of patients with stage III/IV cancer. However, many …

Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …

Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns
that mediate well established cytokine-driven pathways, activating NF-κB together with …

The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …