Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

Increase of allergic conditions has occurred at the same pace with the Great Acceleration,
which stands for the rapid growth rate of human activities upon earth from 1950s. Changes …

Epigenetic mechanisms represent potential molecular routes which could bridge the gap
between genetic background and environmental risk factors contributing to the …

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology
remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized …

The epithelial barrier is the first line of defense that forms a protective barrier against
pathogens, pollutants, and allergens. Epithelial barrier dysfunction has been recently …

Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions
that share strong genetic and environmental components. Diagnosis relies on clinical history …