Antimalarial drug resistance in Africa: the calm before the storm?
MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia
AA Fola, SM Feleke, H Mohammed, BG Brhane… - Nature …, 2023 - nature.com
Diagnosis and treatment of Plasmodium falciparum infections are required for effective
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …
Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda
Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …
Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia
SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa
Local and cross-border importation remain major challenges to malaria elimination and are
difficult to measure using traditional surveillance data. To address this challenge, we …
difficult to measure using traditional surveillance data. To address this challenge, we …
Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania
Zanzibar has made significant progress toward malaria elimination, but recent stagnation
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …
Molecular markers for malaria genetic epidemiology: progress and pitfalls
Over recent years, progress in molecular markers for genotyping malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …
enabled informative studies of epidemiology and transmission dynamics. Results have …
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
Abstract The Democratic Republic of the Congo (DRC) harbors 11% of global malaria
cases, yet little is known about the spatial and genetic structure of the parasite population in …
cases, yet little is known about the spatial and genetic structure of the parasite population in …
Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa
Next-generation sequencing (NGS) technologies are increasingly being used to address a
diverse range of biological and epidemiological questions. The current understanding of …
diverse range of biological and epidemiological questions. The current understanding of …