Tactile sensory information from facial whiskers provides nocturnal tunnel-dwelling rodents,
including mice and rats, with important spatial and textural information about their immediate …

The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined
system for exploring the link between molecular mechanisms, synaptic circuits, and …

We have developed a method for temporal and regional gene expression targeting
(TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a …

In primary sensory neocortical areas of mammals, the distribution of sensory receptors is
mapped with topographic precision and amplification in proportion to the peripheral receptor …

This year, the field of neuroscience celebrates the 50th anniversary of Mountcastle's
discovery of the cortical column. In this review, we summarize half a century of research and …

At least nine closely related isoforms of adenylyl cyclases (ACs), the enzymes responsible
for the synthesis of cyclic AMP (cAMP) from ATP, have been cloned and characterized in …

The present review focuses on the potential physiological regulations involving different
isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of …

The CCCTC-binding factor (CTCF) is a key molecule for chromatin conformational changes
that promote cellular diversity, but nothing is known about its role in neurons. Here, we …

Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT
levels during this period can have lasting neurobiological and behavioral consequences. It …

Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed.
Evidence is accumulating which suggests that intrinsic mechanisms have a central role in …