This review intends to provide the reader with a clear and concise overview of how
preparative continuous flow organic chemistry could potentially impact on current important …

Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …

We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …

Many reactions show much faster kinetics in microdroplets than in the bulk phase. Most
reported reactions in microdroplets mirror the products found in bulk reactions. However, the …

Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has
been synthesized using continuous flow methodology. Desorption electrospray ionization …

We demonstrate the use of accelerated reactions with desorption electrospray ionization
mass spectrometry (DESI-MS) as a tool for predicting the outcome of microfluidic reactions …

Suzuki cross-coupling is a widely performed reaction, typically using metal catalysts under
heated conditions. Acceleration of the Suzuki cross-coupling reaction has been previously …

Nucleophilic aromatic substitution (SNAr) reactions were optimized using high-throughput
experimentation techniques for execution under flow conditions. A total of 3072 unique …

As the development of microfluidic chip and mass spectrometry, the coupling of chip with
mass spectrometry (Chip-MS) has attracted increasing attention in analytical chemistry. As a …

Traditional methods to discover optimal reaction conditions for small molecule synthesis is a
time‐consuming effort that requires large quantities of material and a significant expenditure …