Osteoporosis (OP) is a kind of systemic metabolic disease characterized by decreased bone
mass and destruction of the bone microstructure. In recent years, it has become an expected …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …

Alzheimer's disease (AD) is a progressive degenerative disorder and a leading cause of
dementia in the elderly. The etiology of AD is multifactorial, including an increased oxidative …

Skeletal development is a complex process regulated by multifactorial signaling cascades
that govern proper tissue specific cell differentiation and matrix production. The influence of …

One of the potential contributing factors for iron overload-induced osteoporosis is the iron
toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and …

Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide
also secreted by non-neural cells, including chondrocytes. PACAP signaling is involved in …

Joint tissues like synovium, articular cartilage, meniscus and subchondral bone, are targets
for neuropeptides. Resident cells of these tissues express receptors for various …

Abstract Purpose Although more than 18,000,000 fractures occur each year in the US,
methods to promote fracture healing still rely primarily on fracture stabilization, with use of …

Abstract Dipeptidyl peptidase 4 (DPP4) is a conserved exopeptidase with an important
function in protein regulation. The activity of DPP4, an enzyme which can either be anchored …

Human dental pulp stem cells (DPSCs) have high clonogenic and proliferative potential. We
previously reported that a helioxanthin derivative (4-(4-methoxyphenyl) pyrido [40, 30: 4, 5] …