Curcumin, an active component of the rhizome turmeric, has gained much attention as a
plant-based compound with pleiotropic pharmacological properties. It possesses anti …

A novel strategy in metallodrug discovery today is incorporating clinically approved drugs
into metal complexes as coordinating ligands. Using this strategy, various drugs have been …

The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

A series of novel ruthenium (II) arene RAPTA type derivatives (arene= cymene,
hexamethylbenzene) containing curcumin-based ligands (curcH= curcumin, bdcurcH …

Translation is the most energy-consuming activity within cells. Due to metabolic demands
and high proliferation, cancer cells require elevated rates of protein synthesis, thus providing …

Colorectal cancer (CRC) is one of the intimidating causes of death around the world. CRC
originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair …

Curcuminoids are highly bioactive, polyphenolic compounds derived from the roots of
Curcuma longa. Among them, curcumin is the best known and shows potential against …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Organometallic Ru (II)-cymene complexes linked to ferrocene (Fc) via nitrogen heterocycles
have been synthesized and studied as cytotoxic agents. These compounds are analogues …

Upon exploration of the chemistry of the combination of ruthenium/arene with anthraquinone
alizarin (L), three new complexes with the general formulas [Ru (L) Cl (η6-p …