Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia
and abnormal, hypersynchronous oscillations that manifest behaviorally as absence …

Sequencing-based studies have identified novel risk genes associated with severe
epilepsies and revealed an excess of rare deleterious variation in less-severe forms of …

Common diseases are often complex because they are genetically heterogeneous, with
many different genetic defects giving rise to clinically indistinguishable phenotypes. This has …

Absence seizures are a common seizure type in children with genetic generalized epilepsy
and are characterized by a temporary loss of awareness, arrest of physical activity, and …

It is well established that idiopathic generalized epilepsies (IGEs) show a polygenic origin
and may arise from dysfunction of various types of voltage-and ligand-gated ion channels …

Human genome variation contributes to diversity in neurodevelopmental outcomes and
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …

T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are
involved in a wide variety of physiological functions, especially in nervous systems. Their …

Low voltage-activated (LVA) T-type calcium channels are well regarded as a key
mechanism underlying the generation of neuronal burst-firing. Their low threshold for …

Hereditary cerebellar ataxias (CAs) are neurodegenerative disorders clinically characterized
by a cerebellar syndrome, often accompanied by other neurological or non-neurological …