Cell penetrating peptides: classification, mechanisms, methods of study, and applications

A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

Physicochemical characteristics of droplet interface bilayers

Y Huang, GG Fuller, VC Suja - Advances in Colloid and Interface Science, 2022 - Elsevier
Droplet interface bilayer (DIB) is a lipid bilayer formed when two lipid monolayer-coated
aqueous droplets are brought in contact within an oil phase. DIBs, especially post …

[HTML][HTML] Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers

T Ono, KV Tabata, Y Goto, Y Saito, H Suga, H Noji… - Chemical …, 2023 - pubs.rsc.org
Cyclic peptides that passively penetrate cell membranes are under active investigation in
drug discovery research. PAMPA (Parallel Artificial Membrane Permeability Assay) and …

Control of enzyme reaction initiation inside giant unilamellar vesicles by the cell-penetrating peptide-mediated translocation of cargo proteins

A Miwa, K Kamiya - ACS Synthetic Biology, 2022 - ACS Publications
Cell-penetrating peptides (CPPs) play important roles in directly delivering biomolecules,
such as DNA, proteins, and peptides, into living cells. In artificial lipid membranes, such as …

Structural bases for the involvement of phosphatidylinositol-4, 5-bisphosphate in the internalization of the cell-penetrating peptide Penetratin

L Bechtella, E Chalouhi, P Milán Rodríguez… - ACS Chemical …, 2022 - ACS Publications
Cell-penetrating peptides cross cell membranes through various parallel internalization
pathways. Herein, we analyze the role of the negatively charged lipid phosphatidylinositol-4 …

Effect of membrane potential on entry of lactoferricin B-derived 6-residue antimicrobial peptide into single Escherichia coli cells and lipid vesicles

F Hossain, H Dohra, M Yamazaki - Journal of Bacteriology, 2021 - Am Soc Microbiol
An antimicrobial peptide (AMP) derived from lactoferricin B, LfcinB (4–9)(RRWQWR), and
lissamine rhodamine B red-labeled peptide [Rh-LfcinB (4–9)] exhibit strong antimicrobial …

Role of negatively charged lipids achieving rapid accumulation of water-soluble molecules and macromolecules into cell-sized liposomes against a concentration …

H Sugiyama, T Osaki, S Takeuchi, T Toyota - Langmuir, 2021 - ACS Publications
Liposomes, molecular self-assemblies resembling biological membranes, are a promising
scaffold to investigate the physicochemical logic behind the complexity of living cells …

[HTML][HTML] Translational use of homing peptides: Tumor and placental targeting

AA Alobaid, MWA Skoda, LK Harris… - Journal of Colloid and …, 2024 - Elsevier
Hypothesis Tissue-specific homing peptides have been shown to improve chemotherapeutic
efficacy due to their trophism for tumor cells. Other sequences that selectively home to the …

Processes and mechanisms underlying burst of giant unilamellar vesicles induced by antimicrobial peptides and compounds

MM Billah, M Ahmed, MZ Islam, M Yamazaki - Biochimica et Biophysica …, 2024 - Elsevier
To clarify the damage of lipid bilayer region in bacterial cell membrane caused by
antimicrobial peptides (AMPs) and antimicrobial compounds (AMCs) to cell membranes …

Leaflet-dependent effect of anionic lipids on membrane insertion by cationic cell-penetrating peptides

SC Povilaitis, LJ Webb - The journal of physical chemistry letters, 2023 - ACS Publications
Cationic membrane-permeating peptides can cross membranes unassisted by
transmembrane protein machinery, and there is consensus that anionic lipids facilitate this …