Inflammation and fibrosis in murine models of heart failure

L Bacmeister, M Schwarzl, S Warnke, B Stoffers… - Basic research in …, 2019 - Springer
Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases

D Lindner, A Fitzek, H Bräuninger… - JAMA …, 2020 - jamanetwork.com
Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be
documented in various tissues, but the frequency of cardiac involvement as well as possible …

Biomarker‐guided individualization of antibiotic therapy

LBS Aulin, DW de Lange, MAA Saleh… - Clinical …, 2021 - Wiley Online Library
Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a
major clinical challenge, and is expected to become even more urgent with the global rise of …

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

H Bräuninger, B Stoffers, ADE Fitzek… - Cardiovascular …, 2022 - academic.oup.com
Aims Cardiac involvement in COVID-19 is associated with adverse outcome. However, it is
unclear whether cell-specific consequences are associated with cardiac SARS-CoV-2 …

Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation

K Scherschel, K Hedenus, C Jungen… - Science translational …, 2019 - science.org
Atrial fibrillation (AF), the most common sustained heart rhythm disorder worldwide, is linked
to dysfunction of the intrinsic cardiac autonomic nervous system (ICNS). The role of ICNS …

Chronic activation of tubulin tyrosination improves heart function

N Pietsch, CY Chen, S Kupsch, L Bacmeister… - Circulation …, 2024 - ahajournals.org
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic
disorder caused by sarcomeric gene variants and associated with left ventricular …

Unraveling the molecular crosstalk and immune landscape between COVID-19 infections and ischemic heart failure comorbidity: New insights into diagnostic …

G Wu, J Zhou, H Ren, Y Qin, D Qian, Q Hu, P Xu, T Yu… - Cellular …, 2023 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19), resulting from severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), remains a persistent global health …

G protein-coupled receptor 15 expression is associated with myocardial infarction

T Haase, C Müller, B Stoffers, P Kirn… - International journal of …, 2022 - mdpi.com
Beyond the influence of lifestyle-related risk factors for myocardial infarction (MI), the
mechanisms of genetic predispositions for MI remain unclear. We sought to identify and …

[HTML][HTML] Single cell study of cellular diversity and mutual communication in chronic heart failure and drug repositioning

J Wan, Z Zhang, S Tian, S Huang, H Jin, X Liu… - Genomics, 2022 - Elsevier
Abstract Non-cardiomyocytes (non-CMs) play an important role in the process of cardiac
remodeling of chronic heart failure. The mechanism of non-CMs transit and interact with …

Reynoutrin improves ischemic heart failure in rats via targeting S100A1

W Yang, H Tu, K Tang, H Huang, S Ou… - Frontiers in …, 2021 - frontiersin.org
This study investigated the effects of reynoutrin on the improvement of ischemic heart failure
(IHF) and its possible mechanism in rats. The rat heart failure model was established by …