Medicinal chemistry strategies targeting PRMT5 for cancer therapy
S Fu, Q Zheng, D Zhang, C Lin, L Ouyang… - European Journal of …, 2022 - Elsevier
Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …
physiological function is mono-and symmetric dimethylation of arginine, has drawn …
[HTML][HTML] Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms
Y Chen, X Shao, X Zhao, Y Ji, X Liu, P Li… - Biomedicine & …, 2021 - Elsevier
The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
PRMT5 activates AKT via methylation to promote tumor metastasis
Abstract Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase
generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …
generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …
metabolism and cell growth by sensing diverse environmental signals, including amino …
Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer
Abstract Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and
symmetric di-methylation on arginine residues and has emerged as a potential antitumor …
symmetric di-methylation on arginine residues and has emerged as a potential antitumor …
Master kinase PDK1 in tumorigenesis
N Zheng, J Wei, D Wu, Y Xu, J Guo - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
phosphoinositide-dependent protein kinase 1 (PDK1) is considered as master kinase
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
Y Sun, X Jin, J Meng, F Guo, T Chen, X Zhao… - The EMBO …, 2023 - embopress.org
The Hippo signaling axis is a tumor suppressor pathway that is activated by various extra‐
pathway factors to regulate cell differentiation and organ development. Recent studies have …
pathway factors to regulate cell differentiation and organ development. Recent studies have …
The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression
B Yao, S Zhu, X Wei, MK Chen, Y Feng, Z Li, X Xu… - Molecular Cancer, 2022 - Springer
Abstract Background Prostate cancer (PCa) is the most frequently diagnosed malignancy in
men, and its mechanism remains poorly understood. Therefore, it is urgent to discover …
men, and its mechanism remains poorly understood. Therefore, it is urgent to discover …
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription
and genome stability. Dysregulation of BRD4 is frequently observed in various human …
and genome stability. Dysregulation of BRD4 is frequently observed in various human …
A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance
A Alegre-Martí, A Jiménez-Panizo… - Science …, 2023 - science.org
Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …
insensitivity syndrome may profoundly influence its structure, protein interaction network …